- Miley Cyrus - Miley Stewart
- Miley Cyrus - Luann Stewart
- Billy Ray Cyrus - Robby Ray Stewart
- Billy Ray Cyrus - Bobby Stewart
- Creagen Dow - Donny
- Ryan Whitney Newman - Young Miley Stewart
- Tiffany Thornton - Becky
- Teo Olivares - Max
- Ashley Tisdale - Maddie Fitzpatrick
- Lee Reherman - Chet
- Leigh-Allyn Baker - Mickey
- Kirby Bliss Blanton - Becca Weller
- Cole Sprouse - Cody Martin
- Donny Osmond - Donny Osmond
- Ellen Albertini Dow - Kathrine McCord
- Phoebe Snow - Mrs. Schablansky
- Ryan Pinkston - Connor
- Natalia Baron - Teresa
- June Angela - Cassie
- Joey Fatone - Joey Vitolo
- Kenneth Mars - Gunther
- China Anne McClain - Isabel
- Savannah Stehlin - Patty Dontzig
- Daniel Booko - Stavros
- Camryn Manheim - Margo
- Gregory Itzin - William Harris
- Carrie Ann Inaba - Tina
- Sydney Park - Kelsey DiAria
- Karina Smirnoff - Madame Escajeda
- Michael McDonald - Chef Duncan Keats
- Susan Ruttan - Grandma
- Sterling Knight - Lucas
- Ed Begley Jr. - Woody
- Rachel York - Isis
- Drew Osborne - Willis
- Tom McGowan - Leo
- Debby Ryan - Bailey Pickett
- Patrick Kerr - Simon
- Terry Rhoads - Mack
- Kunal Sharma - Evan
- John D'Aquino - President Richard Martínez
- Lindsey Stoddart - Margo Diamond
- Tim Russ - Dr. Meyer
- Amir Talai - Sanjay
- Troy Evans - Jerry
- Josie Loren - Holly
- Sean Whalen - Moose Master Mike
- Lisa Rinna - Francesca
- Michael Steger - Guillermo Montoya
- Juliette Goglia - Angela Vitolo
- Roxanne Beckford - Clementine
- David Archuleta - David Archuleta
- Dwayne Johnson - Dwayne "The Rock" Johnson
- Shelley Berman - Dr. Froman
- Cheryl Hines - Catherine York
- Andrew Lewis Caldwell - Thor
- Mitzi McCall - Woman
- Nancy O'Dell - Nancy O'Dell
- Aimee Teegarden - Melissa
- Selena Gómez - Mikayla Skeech
- Sara Erikson - Candice
- Alison Brie - Nina
- Andre Jamal Kinney - Cooper Montgomery
- Gwendoline Yeo - Bree Samuels
- Brian Kubach - Jeremy
- Khary Payton - Roger the Director
- Greg Baker - Mr. Corelli
- Anita Finlay - Jeanette Harris
- Christian Serratos - Alexa
- Ray Romano - Ray Romano
- Jodi Shilling - Robin
- Wayne Wilderson - Officer DiAria
- Derek Basco - MTB Host
- Summer Bishil - Rachel
- Madison Pettis - Sophie Martínez
- Bubba Lewis - Matt Marshall
- Kyle Kaplan - Chad the Chomper
- Gina DeVivo - Heather
- Ernie Grunwald - Ed
- Meshach Taylor - Dahliano
- Corbin Bleu - Johnny Collins
- Laird Macintosh - Agent Kaplon
- Daniel Samonas - Josh
- Richard Pierre-Louis - Taylor Kingsford
- Diego J. Torres - Adam
- Melise - Rachel
- Cooper Thornton - Mr. Picker
- Sierra McCormick - Gillian
- Richard Portnow - Marty Kline
- Austin Butler - Toby
- Austin Butler - Derek Hanson
- Andy Pessoa - Young Oliver
- Matt Prokop - Troy McCann
- Davis Cleveland - Little Boy
- Brooke Shields - Susan Stewart
- Brenda Song - London Tipton
- Dylan Sprouse - Zack Martin
- Rizwan Manji - Ajay
- Peter Vogt - Mr. Dontzig
- Antony Del Rio - Bobby
- Regi Davis - Jay Demopoulos
- Bradley Dodds - Spartacus
- Robert Costanzo - Jersey Guy
- Robert Costanzo - Al Blaine
- Fred Stoller - Howard Goldwasser
- Philip Anthony-Rodriguez - Shawn Nahnah
- Mark Hapka - Austin
- Michelle DeFraites - Barbie
- Genevieve Hannelius - Tiffany
- Kat Graham - Allison
- Buddy Handleson - Boy
- Simon Curtis - Tim
- Chris Zylka - Gabe Lamotti
- Aimee Carrero - Mia
- Kara DioGuardi - Kara DioGuardi
- Hunter King - Bridget
- Charles Shaughnessy - Byron
- Dana Daurey - Veronica
- Mary Scheer - Norma
- Ayesha Curry - Andrea
- Kelli Goss - Chelsea
- Lucas Cruikshank - Kyle McIntyre
- P.J. Byrne - Baz B. Berkley
- Sterling Sulieman - Dwight
- Jesse Head - Trent Stone
- Kiara Muhammad - Rosanna
- Angus T. Jones - T.J.
- Ray Liotta - Principal Luger
- Angel Parker - Sharon
- Sheryl Crow - Sheryl Crow
- Christine Taylor - Lori
- John Cena - John Cena
- Morgan York - Sarah
- Zach Callison - Douglas
- Gildart Jackson - Quinn
- Brighton Sharbino - Cammi
- Jay Leno - Jay Leno
- Robin Roberts - Robin Roberts
- Frances Callier - Roxy Roker
- Noah Cyrus - Girl with ice cream
- Noah Cyrus - Little Shopper
- Noah Cyrus - Girl in Ball Pit
- Noah Cyrus - Girl
- Noah Cyrus - Girl on Rope
- Brie Gabrielle - Anne
- Nate Hartley - Aaron
- Jon Cryer - Ken Truscott
- Drew Roy - Jesse
- John Eric Bentley - Judge Joe Barrett
- Tammin Sursok - Siena
- Chris Brochu - Dex
- Windell Middlebrooks - Plumber
- Nicole Gale Anderson - Marrissa Hughes
- Tiffany Espensen - Samantha
- Tanner Maguire - Jeffrey
- Cody Linley - Jake Ryan
- R. Brandon Johnson - Brian Winters
- Erin Matthews - Karen Kunkle
- Jesse McCartney - Jesse McCartney
- Brandi Cyrus - Guitarist
- Brandi Cyrus - Customer #1
- Paul Vogt - Mr. Dontzig
- Paul Vogt - Donna
- Nick Jonas - Nick Jonas
- Kevin Jonas - Kevin Jonas
- Heather Locklear - Heather Truscott
- Vicki Lawrence - Ruthie Ray Stewart
- Dolly Parton - Aunt Dolly
- Mateo Arias - Kid
- Ruth Williamson - Loretta
- Patrick Ryan Anderson - Todd
- Michael Boatman - Randall Harrison
- Edie McClurg - Cindy Merriwether
- Sheryl Lee Ralph - Clarice Johnson
- Shanica Knowles - Amber Addison
- Anna Maria Perez de Tagle - Ashley Dewitt
- Romi Dames - Traci Van Horn
- Rebecca Creskoff - Nurse Carol
- Lisa Arch - Liza
- Stephen Full - Director
- Michael Kagan - Colin Lassiter
- Sandy Brown - Wendy
- Chelsea Harris - Gina
- Susan James Berger - Aunt Harriet
- Nathan Norman - Guy #1
- Bjorn Wilde - Beach Guy
- Rae'Ven Larrymore Kelly - Olivia Montgomery
- D. Elliot Woods - Derek The Bouncer
- Helen Duffy - Queen Elizabeth II
- Jeff Mallare - Opponent
- Abigail Marlowe - Gwendolyn - Servant
- Milo Stokes - Guy #2
- Milo Stokes - Milo
- Jessica D. Stone - Girl #1
- Jessica D. Stone - Spectator
- Kira Legg - Shopper
- Rachel G. Fox - Girl #2
- Nika King - Coach Lewis
- Larry Udy - Plumber
- Susan Boyajian - Mother
- Daniel E. Smith - Henry
- Luke Strode - Concert Guy
- Rafael Rojas III - Jay
- Brandon Stacy - Liza's Assistant
- Hyosun Choi - Jake Ryan Fan #1
- Diane Sellers - Mrs. Bellows
- Diane Sellers - Mrs. Belloows
- Taylor Emerson - Jake Ryan Fan #2
- Kirsten Maryott - Female Automated
- Jay Brian Winnick - Tony the Janitor
- Charlie Hartsock - Check Guy
- Blake Berris - Ghoul #1
- Dollar Tan - Ghoul #2
- Monika Jolly - Sandy
- David Michie - Delivery Man
- David Michie - Courier #1
- Frances Bay - Cathy
- Annie Korzen - Sylvia
- Marius Mazmanian - Sid
- Tanya Raisa - Candy Striper
- Ray Auxias - Sean
- Vanessa Born - Carmen
- Anthony Ocasio - Juggler
- Dennis Singletary - Principal Marsh
- RJ Mitte - School Jock
- Chyna Chuu - Brianna
- Bianca Ruiz Brockl - Little Girl
- Bianca Ruiz Brockl - Captain #2
- Matt Winston - Fermine
- Matt Winston - Fermine (archive footage)
- Ameenah Kaplan - Mom
- Krista Swan - Caitlan
- Tera Hendrickson - Mrs. Espinosa
- Avriel Epps - Girl
- David Haack - Davie
- David Haack - Guitarist
- Adam Cagley - Football Guy
- Alex Collins - Guy #2
- Yvette Cason - Teacher
- Jessie T. Usher - Guy
- Brooks Almy - Mrs. McDermott
- David Douglas - Stage Manager
- Annabelle Milne - Punk Rock Girl
- David Koechner - Uncle Earl
- David Koechner - Uncle Earl (archive footage)
- Brett Wagner - Arlo
- Andrea Jung - Juror #1
- Keegan McFadden - Nick
- Jan-Michael Rosner - Juror #2
- KImberly Adair - Diane
- KImberly Adair - GPS Lady (voice)
- Cece Tsou - Technician #1
- Cazzie David - Cazzie
- Jorge Luis Abreu - Maitre'd
- Larry David - Larry David
- Kelly Gould - Little Girl
- Louis Iacoviello - The Man
- Sam Zeller - Mr. Annihilator
- Tiya Sircar - Natasha
- Anita Morales - Old Lady
- Aaron Hill - Wayne
- Hayley Holmes - Chess Girl
- Cassandra Jean Amell - Pretty Girl (uncredited)
- Rick Cornette - Guiseppe
- Jennifer Robertson - Flight Attendant
- Amanda Hall - Blonde Girl at Beach
- Kelli Dawn Hancock - Woman in Hat
- Phillip Jordan - Sound Engineer
- Izzy Diaz - Auggie
- Jen Lilley - Swim Suit Model
- Kassie Spielman - Nikki
- Travis Winfrey - Stage Manager
- AJ Meijer - Kid
- Paul Michael Ramirez - Man
- Cutter Garcia - Paulie The Paparazzo
- Cutter Garcia - Paulie the Paparazzo
- Gilbert Gottfried - Barney Bittman
- Richard Chiu - Band Member
- Nick Gillie - Tow Truck Driver
- Bob Bledsoe - Frank
- Joe Jonas - Joe Jonas (archive footage)
- Joe Jonas - Joe Jonas
- Michelle Merring - Ed's Mother
- Kieran Newton - Jimmy
- Merritt Bailey - Construction Worker
- Gabriel Praddo - Astronaut Hector
- Cornell Womack - Armand
- Victor Yerrid - Pancake Buffalo
- Wayne Thomas Yorke - Phil
- Alvin Lam - Customer #2
- Matt Merchant - Devin
- Angela Trimbur - Girl
- Alec Ledd - Stage Manager
- Alec Ledd - Ronnie
- Jillian Reeves - Woman
- Wendy Worthington - Annie
- Cubbie Kile - Young Lilly
- Erika Medina - Girl
- Scotty Noyd Jr. - Little Boy
- William Christian - Edward Johnson
- James Leo Ryan - Man #2
- Kelli Kirkland - Woman
- Americus Abesamis - Hiro
- Tim Chiou - Stage Manager
- Nicole Randall Johnson - Lorraine
- Dani Thorne - Dani
- David Bickford - Dr. Reynolds
- Angela Malhotra - Dental Hygienist
- Charlene deGuzman - Band Member
- Charlene deGuzman - Drummer
- Claudia Choi - Mother
- Brian Nolan - Host
- Haley Tju - Girl
- Shantiel Alexis Vazquez - Rico's Employee
- Isabella Acres - Kid #1
- Nadine Crocker - Pretty Girl
- Pia Glenn - Mother
- Rubén Garfias - Beowulf
- Jeff Marchelletta - Steve Meyer
- Maribeth Monroe - White House Guide
- Romina - Lamp Buyer
- Chuti Tiu - Maria Brown
- Alan Wong - Clovis
- Luke Davis - Douggie's Friend
- Jack Merrill - Mr. Meadows
- Rob Reiner - Rob Reiner
- Alana Gordillo - Maggie
- Bryan Gaw - Dancer
- Karen-Eileen Gordon - Nurse
- Danielle E. Hawkins - Dancer
- Donna Pieroni - Big Gal
- Elena Talan - Meeva
- Paul Vandervort - Young Man
- Steve Vinovich - Principal Weebie
- Samantha Cope - Theresa Hartman
- Courtney Mun - Amy
- Di Quon - Jenny the Waitress
- Jill Basey - Older Woman
- Michael Cornacchia - Cupid Preacher
- Robert Ochoa - Camper #1
- Jeff Clarke - Sound Engineer
- Jameson Moss - Frankie
- Dean Francois - Doctor
- Jared Hillman - Gil
- Terrell Lee - Male Nurse
- Carla Jimenez - Opera Singer
- Clint Culp - Dewey
- Ruben Pla - Handyman
- Ryoji Kure - Band #1
- Bay Dariz - Band #2
- Mary-Charles Jones - Young Miley Stewart
- Clent Bowers - Choir Guy
- Reggie Brown - President
- Fuschia! - Choir Woman
- Robert Towers - Old Man
- Robert Towers - Albert Einstein
- Karen Maruyama - Dr. Yamada
- LaTonya Holmes - Choir Member
- LaTonya Holmes - Choir Woman
- Nay Nay Kirby - Chelsea
- Valerie Mahaffey - Ms. Jameson
- Phil McGraw - Phil McGraw
- Geoffrey Plitt - Lenny
- Stacy Jones - Drummer
- Robson Vieira - Paparazzi
- Pamela Dunlap - Mrs. Elderman
- Michael Ensign - Mr. Elderman
- Kelly Ripa - Kelly Ripa
- Julia Cho - Luna
- Tug Coker - Reptile Wrangler
- Chris Grabher - Pippin
- Natalie Lander - Annie
- Olivia Molina - Miley's Friend
- Monica Pinto - Lesley
- Eddie Diaz - Nestor
- Phill Lewis - Marion Moseby
- Kim C. Friese
- Barry O'Brien
- Rich Correll
- Richard G. King
- Michael Poryes
- Steven Peterman
Edie McClurg hace el papel de Cindy Merriwether.
Richard Portnow interpreta a Marty Kline en la serie.
Rob Reiner interpreta a Rob Reiner en la serie.
Miley Cyrus interpreta a Miley Stewart en la serie.
Emily Osment interpreta a Lilly Truscott en la serie.
Jason Earles interpreta a Jackson Stewart en la serie.
Billy Ray Cyrus hace el papel de Robby Ray Stewart.
Moisés Arias interpreta a Rico Suave en la serie.
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